Ontology highlight
ABSTRACT:
SUBMITTER: Krause N
PROVIDER: S-EPMC8867398 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Krause Nicolas N Mengwasser Jörg J Phithak Elpida E Beato Francisca F Appis Marc M Milford Edgar Louis EL Pratschke Johan J Sauer Igor I Kuehl Anja A Vogel Arndt A Goodyear Michael M Hammerich Linda L Tacke Frank F Haas Johanna Faith JF Müller Tobias T Utku Nalan N
Frontiers in immunology 20220208
A subset of T regulatory cells (Tregs), identified by TIRC7 (T cell immune response cDNA 7) expression is designated as Immune Regulatory 1 Cells (IR1 cells). TIRC7 is an immune checkpoint inhibitor, co-localized with the T- cell receptor, HLA-DR and CTLA-4 during T-cell activation, which delivers regulatory signals <i>via</i> binding to its ligand, HLA-DR <i>α</i>2 domain. IR1 cells express FOXP3, and multiple other markers associated with immune suppression. They constitute as much as 10% of T ...[more]