Dataset Information

Cardiovascular profiling in the diabetic continuum: results from the population-based Gutenberg Health Study.

ABSTRACT:

Aims

To assess the prevalence of type 2 diabetes mellitus (T2DM) and prediabetes in the general population and to investigate the associated cardiovascular burden and clinical outcome.

Methods and results

The study sample comprised 15,010 individuals aged 35-74 years of the population-based Gutenberg Health Study. Subjects were classified into euglycaemia, prediabetes and T2DM according to clinical and metabolic (HbA1c) information. The prevalence of prediabetes was 9.5% (n = 1415) and of T2DM 8.9% (n = 1316). Prediabetes and T2DM showed a significantly increased prevalence ratio (PR) for age, obesity, active smoking, dyslipidemia, and arterial hypertension compared to euglycaemia (for all, P < 0.0001). In a robust Poisson regression analysis, prediabetes was established as an independent predictor of clinically-prevalent cardiovascular disease (PR_prediabetes 1.20, 95% CI 1.07-1.35, P = 0.002) and represented as a risk factor for asymptomatic cardiovascular organ damage independent of traditional risk factors (PR 1.04, 95% CI 1.01-1.08, P = 0.025). Prediabetes was associated with a 1.5-fold increased 10-year risk for cardiovascular disease compared to euglycaemia. In Cox regression analysis, prediabetes (HR 2.10, 95% CI 1.76-2.51, P < 0.0001) and T2DM (HR 4.28, 95% CI 3.73-4.92, P < 0.0001) indicated for an increased risk of death. After adjustment for age, sex and traditional cardiovascular risk factors, only T2DM (HR 1.89, 95% CI 1.63-2.20, P < 0.0001) remained independently associated with increased all-cause mortality.

Conclusion

Besides T2DM, also prediabetes inherits a significant cardiovascular burden, which translates into poor clinical outcome and indicates the need for new concepts regarding the prevention of cardiometabolic disorders.

SUBMITTER: Schmitt VH

PROVIDER: S-EPMC8873120 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Publications

Cardiovascular profiling in the diabetic continuum: results from the population-based Gutenberg Health Study.

Schmitt Volker H VH Leuschner Anja A Jünger Claus C Pinto Antonio A Hahad Omar O Schulz Andreas A Arnold Natalie N Tröbs Sven-Oliver SO Panova-Noeva Marina M Keller Karsten K Zeller Tanja T Beutel Manfred M Pfeiffer Norbert N Strauch Konstantin K Blankenberg Stefan S Lackner Karl J KJ Prochaska Jürgen H JH Wild Philipp S PS Münzel Thomas T

Clinical research in cardiology : official journal of the German Cardiac Society 20210624 3

<h4>Aims</h4>To assess the prevalence of type 2 diabetes mellitus (T2DM) and prediabetes in the general population and to investigate the associated cardiovascular burden and clinical outcome.<h4>Methods and results</h4>The study sample comprised 15,010 individuals aged 35-74 years of the population-based Gutenberg Health Study. Subjects were classified into euglycaemia, prediabetes and T2DM according to clinical and metabolic (HbA1c) information. The prevalence of prediabetes was 9.5% (n = 1415 ...[more]

PMID: 34169342

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Dataset Information

Cardiovascular profiling in the diabetic continuum: results from the population-based Gutenberg Health Study.

Aims

Methods and results

Conclusion

Publications

Cardiovascular profiling in the diabetic continuum: results from the population-based Gutenberg Health Study.

Similar Datasets

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