Horizontal mtDNA transfer between cells is common during mouse development.
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ABSTRACT:
SUBMITTER: Marti Gutierrez N
PROVIDER: S-EPMC8873606 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Publications
Horizontal mtDNA transfer between cells is common during mouse development.
Marti Gutierrez Nuria N Mikhalchenko Aleksei A Ma Hong H Koski Amy A Li Ying Y Van Dyken Crystal C Tippner-Hedges Rebecca R Yoon David D Liang Dan D Hayama Tomonari T Battaglia David D Kang Eunju E Lee Yeonmi Y Barnes Anthony Paul AP Amato Paula P Mitalipov Shoukhrat S
iScience 20220210 3
Cells transmit their genomes vertically to daughter cells during cell divisions. Here, we demonstrate the occurrence and extent of horizontal mitochondrial (mt)DNA acquisition between cells that are not in a parent-offspring relationship. Extensive single-cell sequencing from various tissues and organs of adult chimeric mice composed of cells carrying distinct mtDNA haplotypes showed that a substantial fraction of individual cardiomyocytes, neurons, glia, intestinal, and spleen cells captured do ...[more]
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