Ontology highlight
ABSTRACT:
SUBMITTER: Feng Y
PROVIDER: S-EPMC8879513 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Feng Yan Y Xie Kun K Yin Yanxin Y Li Bingyu B Pi Chenyu C Xu Xiaoqing X Huang Tao T Zhang Jingming J Wang Bo B Gu Hua H Fang Jianmin J
Life (Basel, Switzerland) 20220121 2
B7-H3 plays an important role in tumor apoptosis, proliferation, adhesion, angiogenesis, invasion, migration, and evasion of immune surveillance. It is overexpressed in various human solid tumor tissues. In patients, B7-H3 overexpression correlates with advanced stages, poor clinical outcomes, and resistance to therapy. The roles of B7-H3 in tumor progression make it a potential candidate for targeted therapy. Here, we generated a mouse anti-human B7-H3 antibody and demonstrated its binding acti ...[more]