Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh AJ
PROVIDER: S-EPMC8886988 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Ghosh Auyon J AJ Hobbs Brian D BD Moll Matthew M Saferali Aabida A Boueiz Adel A Yun Jeong H JH Sciurba Frank F Barwick Lucas L Limper Andrew H AH Flaherty Kevin K Criner Gerard G Brown Kevin K KK Wise Robert R Martinez Fernando J FJ Lomas David D Castaldi Peter J PJ Carey Vincent J VJ DeMeo Dawn L DL Cho Michael H MH Silverman Edwin K EK Hersh Craig P CP
American journal of respiratory and critical care medicine 20220201 3
<b>Rationale:</b> Multiple studies have demonstrated an increased risk of chronic obstructive pulmonary disease (COPD) in heterozygous carriers of the AAT (alpha-1 antitrypsin) Z allele. However, it is not known if MZ subjects with COPD are phenotypically different from noncarriers (MM genotype) with COPD. <b>Objectives:</b> To assess if MZ subjects with COPD have different clinical features compared with MM subjects with COPD. <b>Methods:</b> Genotypes of <i>SERPINA1</i> were ascertained by usi ...[more]