Ontology highlight
ABSTRACT:
SUBMITTER: Smith LK
PROVIDER: S-EPMC8888590 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Smith Lorey K LK Parmenter Tiffany T Kleinschmidt Margarete M Kusnadi Eric P EP Kang Jian J Martin Claire A CA Lau Peter P Patel Riyaben R Lorent Julie J Papadopoli David D Trigos Anna A Ward Teresa T Rao Aparna D AD Lelliott Emily J EJ Sheppard Karen E KE Goode David D Hicks Rodney J RJ Tiganis Tony T Simpson Kaylene J KJ Larsson Ola O Blythe Benjamin B Cullinane Carleen C Wickramasinghe Vihandha O VO Pearson Richard B RB McArthur Grant A GA
Nature communications 20220301 1
Despite the success of therapies targeting oncogenes in cancer, clinical outcomes are limited by residual disease that ultimately results in relapse. This residual disease is often characterized by non-genetic adaptive resistance, that in melanoma is characterised by altered metabolism. Here, we examine how targeted therapy reprograms metabolism in BRAF-mutant melanoma cells using a genome-wide RNA interference (RNAi) screen and global gene expression profiling. Using this systematic approach we ...[more]