Ontology highlight
ABSTRACT:
SUBMITTER: Saenz de Urturi D
PROVIDER: S-EPMC8888704 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Sáenz de Urturi Diego D Buqué Xabier X Porteiro Begoña B Folgueira Cintia C Mora Alfonso A Delgado Teresa C TC Prieto-Fernández Endika E Olaizola Paula P Gómez-Santos Beatriz B Apodaka-Biguri Maider M González-Romero Francisco F Nieva-Zuluaga Ane A Ruiz de Gauna Mikel M Goikoetxea-Usandizaga Naroa N García-Rodríguez Juan Luis JL Gutierrez de Juan Virginia V Aurrekoetxea Igor I Montalvo-Romeral Valle V Novoa Eva M EM Martín-Guerrero Idoia I Varela-Rey Marta M Bhanot Sanjay S Lee Richard R Banales Jesus M JM Syn Wing-Kin WK Sabio Guadalupe G Martínez-Chantar María L ML Nogueiras Rubén R Aspichueta Patricia P
Nature communications 20220301 1
Altered methionine metabolism is associated with weight gain in obesity. The methionine adenosyltransferase (MAT), catalyzing the first reaction of the methionine cycle, plays an important role regulating lipid metabolism. However, its role in obesity, when a plethora of metabolic diseases occurs, is still unknown. By using antisense oligonucleotides (ASO) and genetic depletion of Mat1a, here, we demonstrate that Mat1a deficiency in diet-induce obese or genetically obese mice prevented and rever ...[more]