Ontology highlight
ABSTRACT:
SUBMITTER: Lorente-Canovas B
PROVIDER: S-EPMC8890737 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Lorente-Cánovas Beatriz B Eckrich Stephanie S Lewis Morag A MA Johnson Stuart L SL Marcotti Walter W Steel Karen P KP
PloS one 20220302 3
Tasmanian devil (tde) mice are deaf and exhibit circling behaviour. Sensory hair cells of mutants show disorganised hair bundles with abnormally thin stereocilia. The origin of this mutation is the insertion of a transgene which disrupts expression of the Grxcr1 (glutaredoxin cysteine rich 1) gene. We report here that Grxcr1 exons and transcript sequences are not affected by the transgene insertion in tde homozygous (tde/tde) mice. Furthermore, 5'RACE PCR experiments showed the presence of two d ...[more]