Unknown

Dataset Information

0

Vitamin K status, all-cause mortality, and cardiovascular disease in adults with chronic kidney disease: the Chronic Renal Insufficiency Cohort.


ABSTRACT:

Background

Vascular calcification contributes to cardiovascular disease (CVD) and mortality in individuals with chronic kidney disease (CKD). Vitamin K-dependent proteins function as calcification inhibitors in vascular tissue.

Objectives

We sought to determine the association of vitamin K status with mortality and CVD events in adults with CKD.

Methods

Plasma dephospho-uncarboxylated matrix gla protein ((dp)ucMGP), which increases when vitamin K status is low, and plasma phylloquinone (vitamin K1), which decreases when vitamin K status is low, were measured in 3066 Chronic Renal Insufficiency Cohort participants (median age = 61 y, 45% female, 41% non-Hispanic black, median estimated glomerular filtration rate [eGFR] = 41 mL/min/1.73m2). The association of vitamin K status biomarkers with all-cause mortality and atherosclerotic-related CVD was determined using multivariable Cox proportional hazards regression.

Results

There were 1122 deaths and 599 atherosclerotic CVD events over the median 12.8 follow-up years. All-cause mortality risk was 21-29% lower among participants with plasma (dp)ucMGP <450 pmol/L (n = 2361) compared with those with plasma (dp)ucMGP ≥450 pmol/L (adjusted HRs [95% CIs]: <300 pmol/L = 0.71 [0.61, 0.83], 300-449 pmol/L = 0.77 [0.66, 0.90]) and 16-19% lower among participants with plasma phylloquinone ≥0.50 nmol/L (n = 2421) compared to those with plasma phylloquinone <0.50 nmol/L (adjusted HRs: 0.50, 0.99 nmol/L = 0.84 [0.72, 0.99], ≥1.00 nmol/L = 0.81 [0.70, 0.95]). The risk of atherosclerotic CVD events did not significantly differ across plasma (dp)ucMGP or phylloquinone categories.

Conclusions

Two biomarkers of vitamin K status were associated with a lower all-cause mortality risk but not atherosclerotic CVD events. Additional studies are needed to clarify the mechanism underlying this association and evaluate the impact of improving vitamin K status in people with CKD.

SUBMITTER: Shea MK 

PROVIDER: S-EPMC8895220 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Vitamin K status, all-cause mortality, and cardiovascular disease in adults with chronic kidney disease: the Chronic Renal Insufficiency Cohort.

Shea M Kyla MK   Barger Kathryn K   Booth Sarah L SL   Wang Jifan J   Feldman Harold I HI   Townsend Raymond R RR   Chen Jing J   Flack John J   He Jiang J   Jaar Bernard G BG   Kansal Mayank M   Rosas Sylvia E SE   Weiner Daniel E DE  

The American journal of clinical nutrition 20220301 3


<h4>Background</h4>Vascular calcification contributes to cardiovascular disease (CVD) and mortality in individuals with chronic kidney disease (CKD). Vitamin K-dependent proteins function as calcification inhibitors in vascular tissue.<h4>Objectives</h4>We sought to determine the association of vitamin K status with mortality and CVD events in adults with CKD.<h4>Methods</h4>Plasma dephospho-uncarboxylated matrix gla protein ((dp)ucMGP), which increases when vitamin K status is low, and plasma p  ...[more]

Similar Datasets

| S-EPMC7293206 | biostudies-literature
| S-EPMC10100935 | biostudies-literature
| S-EPMC4268143 | biostudies-literature
| S-EPMC9630782 | biostudies-literature
| S-EPMC7904143 | biostudies-literature
| S-EPMC10440377 | biostudies-literature
| S-EPMC11618244 | biostudies-literature
| S-EPMC7360239 | biostudies-literature
| S-EPMC6383235 | biostudies-literature
| S-EPMC2941985 | biostudies-literature