Ontology highlight
ABSTRACT:
SUBMITTER: Bitter RM
PROVIDER: S-EPMC8896786 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Bitter Ryan M RM Oh SeCheol S Deng Zengqin Z Rahman Suhaila S Hite Richard K RK Yuan Peng P
Science advances 20220304 9
ATP7A and ATP7B, two homologous copper-transporting P1B-type ATPases, play crucial roles in cellular copper homeostasis, and mutations cause Menkes and Wilson diseases, respectively. ATP7A/B contains a P-type ATPase core consisting of a membrane transport domain and three cytoplasmic domains, the A, P, and N domains, and a unique amino terminus comprising six consecutive metal-binding domains. Here, we present a cryo-electron microscopy structure of frog ATP7B in a copper-free state. Interacting ...[more]