Plasma and CSF NfL are differentially associated with biomarker evidence of neurodegeneration in a community-based sample of 70-year-olds.
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ABSTRACT:
SUBMITTER: Dittrich A
PROVIDER: S-EPMC8897823 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
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Plasma and CSF NfL are differentially associated with biomarker evidence of neurodegeneration in a community-based sample of 70-year-olds.
Dittrich Anna A Ashton Nicholas J NJ Zetterberg Henrik H Blennow Kaj K Simrén Joel J Geiger Fiona F Zettergren Anna A Shams Sara S Machado Alejandra A Westman Eric E Schöll Michael M Skoog Ingmar I Kern Silke S
Alzheimer's & dementia (Amsterdam, Netherlands) 20220305 1
Neurofilament light protein (NfL) in cerebrospinal fluid (CSF) and plasma (P) are suggested to be interchangeable markers of neurodegeneration. However, evidence is scarce from community-based samples. NfL was examined in a small-scale sample of 287 individuals from the Gothenburg H70 Birth cohort 1944 study, using linear models in relation to CSF and magnetic resonance imaging (MRI) biomarker evidence of neurodegeneration. CSF-NfL and P-NfL present distinct associations with biomarker evidence ...[more]
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