Ontology highlight
ABSTRACT:
SUBMITTER: Sterling JK
PROVIDER: S-EPMC8898592 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Sterling Jacob K JK Kam Tae-In TI Guttha Samyuktha S Park Hyejin H Baumann Bailey B Mehrabani-Tabari Amir A AA Schultz Hannah H Anderson Brandon B Alnemri Ahab A Chou Shih-Ching SC Troncoso Juan C JC Dawson Valina L VL Dawson Ted M TM Dunaief Joshua L JL
Cell reports 20220201 7
α-synuclein (α-syn) aggregation and accumulation drive neurodegeneration in Parkinson's disease (PD). The substantia nigra of patients with PD contains excess iron, yet the underlying mechanism accounting for this iron accumulation is unclear. Here, we show that misfolded α-syn activates microglia, which release interleukin 6 (IL-6). IL-6, via its trans-signaling pathway, induces changes in the neuronal iron transcriptome that promote ferrous iron uptake and decrease cellular iron export via a p ...[more]