Vitamin A₁/A₂ chromophore exchange: Its role in spectral tuning and visual plasticity.

ABSTRACT: Vertebrate rod and cone photoreceptors detect light via a specialized organelle called the outer segment. This structure is packed with light-sensitive molecules known as visual pigments that consist of a G-protein-coupled, seven-transmembrane protein known as opsin, and a chromophore prosthetic group, either 11-cis retinal ('A₁') or 11-cis 3,4-didehydroretinal ('A₂'). The enzyme cyp27c1 converts A₁ into A₂ in the retinal pigment epithelium. Replacing A₁ with A₂ in a visual pigment red-shifts its spectral sensitivity and broadens its bandwidth of absorption at the expense of decreased photosensitivity and increased thermal noise. The use of vitamin A₂-based visual pigments is strongly associated with the occupatio

SUBMITTER: Corbo JC 

PROVIDER: S-EPMC8900494 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature