Dataset Information
Gene-Environment Interactions for Cardiovascular Disease.
Ontology highlight
ABSTRACT: Purpose of review
We provide an overview of recent findings with respect to gene-environment (GxE) interactions for cardiovascular disease (CVD) risk and discuss future opportunities for advancing the field.Recent findings
Over the last several years, GxE interactions for CVD have mostly been identified for smoking and coronary artery disease (CAD) or related risk factors. By comparison, there is more limited evidence for GxE interactions between CVD outcomes and other exposures, such as physical activity, air pollution, diet, and sex. The establishment of large consortia and population-based cohorts, in combination with new computational tools and mouse genetics platforms, can potentially overcome some of the limitations that have hindered human GxE interaction studies and reveal additional association signals for CVD-related traits. The identification of novel GxE interactions is likely to provide a better understanding of the pathogenesis and genetic liability of CVD, with significant implications for healthy lifestyles and therapeutic strategies.
SUBMITTER: Hartiala JA
PROVIDER: S-EPMC8903169 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Publications
Gene-Environment Interactions for Cardiovascular Disease.
Current atherosclerosis reports 20211014 12
<h4>Purpose of review</h4>We provide an overview of recent findings with respect to gene-environment (GxE) interactions for cardiovascular disease (CVD) risk and discuss future opportunities for advancing the field.<h4>Recent findings</h4>Over the last several years, GxE interactions for CVD have mostly been identified for smoking and coronary artery disease (CAD) or related risk factors. By comparison, there is more limited evidence for GxE interactions between CVD outcomes and other exposures, ...[more]