Ontology highlight
ABSTRACT:
SUBMITTER: Moscvin M
PROVIDER: S-EPMC8903187 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Moscvin Maria M Ho Matthew M Bianchi Giada G
Cancer drug resistance (Alhambra, Calif.) 20211202
Multiple myeloma (MM) is a plasma cell disorder typically characterized by abundant synthesis of clonal immunoglobulin or free light chains. Although incurable, a deeper understanding of MM pathobiology has fueled major therapeutical advances over the past two decades, significantly improving patient outcomes. Proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies are among the most effective anti-MM drugs, targeting not only the cancerous cells, but also the bone marrow microe ...[more]