Dataset Information

Causal Association Between Alcohol Consumption and Atrial Fibrillation: A Mendelian Randomization Study.

ABSTRACT:

Background and objectives

Previous observational studies presented a positive association between alcohol and atrial fibrillation (AF). However, previous studies using genetic polymorphisms on the causal relationship between alcohol consumption and AF have reported conflicting results. This study aimed to evaluate the causality between alcohol consumption and AF using the aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism, which is the genetic variant with the most potent effect on drinking behavior.

Methods

A total of 8,964 participants from the Dong-gu Study were included in the present study. The causal association between alcohol consumption and AF was evaluated through a Mendelian randomization (MR) analysis using the ALDH2 rs671 polymorphism as an instrumental variable.

Results

No significant relationship between alcohol consumption and AF was found in the observational analysis. However, the genetic analysis using the ALDH2 polymorphism showed a significant association in men. In the MR analysis, genetically predicted daily alcohol consumption was positively related to AF.

Conclusions

MR analysis revealed a significant association between the amount of alcohol consumption and AF, which suggests that the association may be causal.

SUBMITTER: Yang JH

PROVIDER: S-EPMC8907994 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Publications

Causal Association Between Alcohol Consumption and Atrial Fibrillation: A Mendelian Randomization Study.

Yang Jung-Ho JH Jeong Ji-An JA Kweon Sun-Seog SS Lee Young-Hoon YH Choi Seong-Woo SW Ryu So-Yeon SY Nam Hae-Sung HS Park Kyeong-Soo KS Kim Hye-Yeon HY Shin Min-Ho MH

Korean circulation journal 20220103 3

<h4>Background and objectives</h4>Previous observational studies presented a positive association between alcohol and atrial fibrillation (AF). However, previous studies using genetic polymorphisms on the causal relationship between alcohol consumption and AF have reported conflicting results. This study aimed to evaluate the causality between alcohol consumption and AF using the aldehyde dehydrogenase 2 (<i>ALDH2</i>) rs671 polymorphism, which is the genetic variant with the most potent effect ...[more]

PMID: 35129315

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Project description:Background The knowledge gap regarding whether the correlation between atrial fibrillation (AF) and dementia in observational studies is causation or driven by other shared risk factors remains substantially unfilled. Methods and Results We performed a comprehensive 2-sample Mendelian randomization study to evaluate the causal effect of AF on overall dementia and its subtypes, including vascular dementia, Alzheimer dementia, Lewy body dementia, and frontotemporal dementia. The primary results in inverse variance-weighted analyses were further validated by various Mendelian randomization sensitivity analyses. Additionally, we conducted multivariable Mendelian randomization to examine 10 candidate mediators of the causal association of AF and dementia. Genetic predisposition to AF was modestly associated with an increased risk of overall dementia (odds ratio, 1.140 [95% CI, 1.023-1.271]; P=0.018) and strongly associated with vascular dementia (odds ratio, 1.350 [95% CI, 1.076-1.695]; P=0.010). Genetically predicted AF indicated neutral effects on Alzheimer dementia, Lewy body dementia, and frontotemporal dementia. In multivariable Mendelian randomization analysis, the total effect of AF on overall dementia was remarkably attenuated by adjusting for genetic effect for ischemic stroke (odds ratio, 1.068 [95% CI, 0.953-1.197]; P=0.259) and low cardiac output (odds ratio, 1.046 [95% CI, 0.926-1.181]; P=0.475), indicating that the causal association of genetically predicted AF with dementia was potentially mediated by ischemic stroke and low cardiac output. The causal effect of genetically predicted AF on dementia was independent of cerebral small-vessel disease and brain volume phenotypes. Conclusions Our findings provided novel evidence supporting the causal effect of genetically predicted AF on dementia mediated by ischemic stroke and low cardiac output. Future clinical trials are warranted to evaluate the potential role of appropriate AF management in dementia prevention.

Dataset Information

Causal Association Between Alcohol Consumption and Atrial Fibrillation: A Mendelian Randomization Study.

Background and objectives

Methods

Results

Conclusions

Publications

Causal Association Between Alcohol Consumption and Atrial Fibrillation: A Mendelian Randomization Study.

Similar Datasets

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