Ontology highlight
ABSTRACT:
SUBMITTER: Bolkan SS
PROVIDER: S-EPMC8915388 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Bolkan Scott S SS Stone Iris R IR Pinto Lucas L Ashwood Zoe C ZC Iravedra Garcia Jorge M JM Herman Alison L AL Singh Priyanka P Bandi Akhil A Cox Julia J Zimmerman Christopher A CA Cho Jounhong Ryan JR Engelhard Ben B Pillow Jonathan W JW Witten Ilana B IB
Nature neuroscience 20220307 3
A classic view of the striatum holds that activity in direct and indirect pathways oppositely modulates motor output. Whether this involves direct control of movement, or reflects a cognitive process underlying movement, remains unresolved. Here we find that strong, opponent control of behavior by the two pathways of the dorsomedial striatum depends on the cognitive requirements of a task. Furthermore, a latent state model (a hidden Markov model with generalized linear model observations) reveal ...[more]