Ontology highlight
ABSTRACT:
SUBMITTER: LaMoia TE
PROVIDER: S-EPMC8916010 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
LaMoia Traci E TE Butrico Gina M GM Kalpage Hasini A HA Goedeke Leigh L Hubbard Brandon T BT Vatner Daniel F DF Gaspar Rafael C RC Zhang Xian-Man XM Cline Gary W GW Nakahara Keita K Woo Seungwan S Shimada Atsuhiro A Hüttemann Maik M Shulman Gerald I GI
Proceedings of the National Academy of Sciences of the United States of America 20220301 10
SignificanceMetformin is the most commonly prescribed drug for the treatment of type 2 diabetes mellitus, yet the mechanism by which it lowers plasma glucose concentrations has remained elusive. Most studies to date have attributed metformin's glucose-lowering effects to inhibition of complex I activity. Contrary to this hypothesis, we show that inhibition of complex I activity in vitro and in vivo does not reduce plasma glucose concentrations or inhibit hepatic gluconeogenesis. We go on to show ...[more]