Ontology highlight
ABSTRACT:
SUBMITTER: Wrapp D
PROVIDER: S-EPMC8916728 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Wrapp Daniel D Ye Xiaohua X Ku Zhiqiang Z Su Hang H Jones Harrison G HG Wang Nianshuang N Mishra Akaash K AK Freed Daniel C DC Li Fengsheng F Tang Aimin A Li Leike L Jaijyan Dabbu Kumar DK Zhu Hua H Wang Dai D Fu Tong-Ming TM Zhang Ningyan N An Zhiqiang Z McLellan Jason S JS
Science advances 20220311 10
Human cytomegalovirus (HCMV) encodes multiple surface glycoprotein complexes to infect a variety of cell types. The HCMV Pentamer, composed of gH, gL, UL128, UL130, and UL131A, enhances entry into epithelial, endothelial, and myeloid cells by interacting with the cell surface receptor neuropilin 2 (NRP2). Despite the critical nature of this interaction, the molecular determinants that govern NRP2 recognition remain unclear. Here, we describe the cryo-EM structure of NRP2 bound to Pentamer. The h ...[more]