Ontology highlight
ABSTRACT:
SUBMITTER: Song H
PROVIDER: S-EPMC8917382 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Song Haikun H Wang Cen C Zhu Chenggang C Wang Ziying Z Yang Huiya H Wu Peng P Cui Xiaotian X Botas Juan J Dang Yongjun Y Ding Yu Y Fei Yiyan Y Lu Boxun B
Proceedings of the National Academy of Sciences of the United States of America 20220301 10
Identifying inhibitors of pathogenic proteins is the major strategy of targeted drug discoveries. This strategy meets challenges in targeting neurodegenerative disorders such as Huntington’s disease (HD), which is mainly caused by the mutant huntingtin protein (mHTT), an “undruggable” pathogenic protein with unknown functions. We hypothesized that some of the chemical binders of mHTT may change its conformation and/or stability to suppress its downstream toxicity, functioning similarly to an “in ...[more]