Ontology highlight
ABSTRACT:
SUBMITTER: Rimkus TK
PROVIDER: S-EPMC8920049 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Rimkus Tadas K TK Arrigo Austin B AB Zhu Dongqin D Carpenter Richard L RL Sirkisoon Sherona S Doheny Daniel D Regua Angelina T AT Wong Grace L GL Manore Sara S Wagner Calvin C Lin Hui-Kuan HK Jin Guangxu G Ruiz Jimmy J Chan Michael M Debinski Waldemar W Lo Hui-Wen HW
Cancer letters 20220212
Whether tumor suppressor candidate 2 (TUSC2) plays an important role in glioblastoma (GBM) progression is largely unknown. Whether TUSC2 undergoes polyubiquitination is unknown. Herein, we report that TUSC2 protein expression is reduced/lost in GBM compared to normal brain due to protein destabilization; TUSC2 mRNA is equally expressed in both tissues. NEDD4 E3 ubiquitin ligase polyubiquitinates TUSC2 at residue K71, and the TUSC2-K71R mutant is resistant to NEDD4-mediated proteasomal degradatio ...[more]