G0S2 regulates innate immunity in Kawasaki disease via lncRNA HSD11B1-AS1.

ABSTRACT:

Background

Kawasaki disease (KD) is a systemic vasculitis that is currently the most common cause of acquired heart disease in children. However, its etiology remains unknown. Long non-coding RNAs (lncRNAs) contribute to the pathophysiology of various diseases. Few studies have reported the role of lncRNAs in KD inflammation; thus, we investigated the role of lncRNA in KD inflammation.

Methods

A total of 50 patients with KD (median age, 19 months; 29 males and 21 females) were enrolled. We conducted cap analysis gene expression sequencing to determine differentially expressed genes in monocytes of the peripheral blood of the subjects.

Results

About 21 candidate lncRNA transcripts were identified. The analyses of transcriptome and gene ontology revealed that the immune

SUBMITTER: Okabe M 

PROVIDER: S-EPMC8922062 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature