Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes.
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ABSTRACT:
SUBMITTER: Hernandez-Alles S
PROVIDER: S-EPMC89229 | biostudies-literature | 1999 Apr
REPOSITORIES: biostudies-literature
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Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes.
Hernández-Allés S S Benedí V J VJ Martínez-Martínez L L Pascual A A Aguilar A A Tomás J M JM Albertí S S
Antimicrobial agents and chemotherapy 19990401 4
We have demonstrated by using an in vitro approach that interruption of the OmpK36 porin gene by insertion sequences (ISs) is a common type of mutation that causes loss of porin expression and increased resistance to cefoxitin in Klebsiella pneumoniae. This mechanism also operates in vivo: of 13 porin-deficient cefoxitin-resistant clinical isolates of K. pneumoniae, 4 presented ISs in their ompK36 gene. ...[more]
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