Molecular basis of AmpC hyperproduction in clinical isolates of Escherichia coli.
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ABSTRACT:
SUBMITTER: Nelson EC
PROVIDER: S-EPMC89235 | biostudies-literature | 1999 Apr
REPOSITORIES: biostudies-literature
Publications
Molecular basis of AmpC hyperproduction in clinical isolates of Escherichia coli.
Antimicrobial agents and chemotherapy 19990401 4
DNA sequencing data showed that five clinical isolates of Escherichia coli with reduced susceptibility to ceftazidime, ceftriaxone, and cefotaxime contain an ampC gene that is preceded by a strong promoter. Transcription from the strong promoter was 8- to 18-fold higher than that from the promoter from a susceptible isolate. RNA studies showed that mRNA stability does not play a role in the control of AmpC synthesis. ...[more]
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