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Molecular basis of AmpC hyperproduction in clinical isolates of Escherichia coli.


ABSTRACT: DNA sequencing data showed that five clinical isolates of Escherichia coli with reduced susceptibility to ceftazidime, ceftriaxone, and cefotaxime contain an ampC gene that is preceded by a strong promoter. Transcription from the strong promoter was 8- to 18-fold higher than that from the promoter from a susceptible isolate. RNA studies showed that mRNA stability does not play a role in the control of AmpC synthesis.

SUBMITTER: Nelson EC 

PROVIDER: S-EPMC89235 | biostudies-literature | 1999 Apr

REPOSITORIES: biostudies-literature

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Molecular basis of AmpC hyperproduction in clinical isolates of Escherichia coli.

Nelson E C EC   Elisha B G BG  

Antimicrobial agents and chemotherapy 19990401 4


DNA sequencing data showed that five clinical isolates of Escherichia coli with reduced susceptibility to ceftazidime, ceftriaxone, and cefotaxime contain an ampC gene that is preceded by a strong promoter. Transcription from the strong promoter was 8- to 18-fold higher than that from the promoter from a susceptible isolate. RNA studies showed that mRNA stability does not play a role in the control of AmpC synthesis. ...[more]

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