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Longevity interventions temporally scale healthspan in Caenorhabditis elegans.

ABSTRACT: Human centenarians and longevity mutants of model organisms show lower incidence rates of late-life morbidities than the average population. However, whether longevity is caused by a compression of the portion of life spent in a state of morbidity, i.e., "sickspan," is highly debated even in isogenic Caenorhabditis elegans. Here, we developed a microfluidic device that employs acoustophoretic force fields to quantify the maximum muscle strength and dynamic power in aging C. elegans. Together with different biomarkers for healthspan, we found a stochastic onset of morbidity, starting with a decline in dynamic muscle power and structural integrity, culminating in frailty. Surprisingly, we did not observe a compression of sickspan in longevity mutants but instead observed a temporal scaling of healthspan. Given the conservation of these longevity interventions, this raises the question of whether the healthspan of mammalian longevity interventions is also temporally scaled.

SUBMITTER: Statzer C

PROVIDER: S-EPMC8924689 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Longevity interventions temporally scale healthspan in Caenorhabditis elegans.

Statzer Cyril C Reichert Peter P Dual Jürg J Ewald Collin Y CY

iScience 20220224 3

Human centenarians and longevity mutants of model organisms show lower incidence rates of late-life morbidities than the average population. However, whether longevity is caused by a compression of the portion of life spent in a state of morbidity, i.e., "sickspan," is highly debated even in isogenic Caenorhabditis elegans. Here, we developed a microfluidic device that employs acoustophoretic force fields to quantify the maximum muscle strength and dynamic power in aging C. eleg ...[more]

PMID: 35310333

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