Presence of cell-free fetal circRNA in maternal plasma.
Ontology highlight
ABSTRACT: Introduction
There is an urgent need to find novel stable cell-free fetal (cff-) RNA in the maternal circulation to facilitate the advance of non-invasive prenatal testing (NIPT) to more effectively avoid birth defects.Methods
CircRNA microarray was used to detect the cff-circRNA in plasma.Results
There were cff-circRNAs from the fetus in the peripheral blood of pregnant women and they persisted even until at least 24 h after delivery. In addition, we found that cff-circRNA might have a specific expression pattern in gestational disease.Conclusions
We demonstrated the presence of cff-circRNA in the maternal circulation, which may shed new light on the development of NIPT.
SUBMITTER: Ran Y
PROVIDER: S-EPMC8924834 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Presence of cell-free fetal circRNA in maternal plasma.
Ran Yuxin Y Chen Ruixin R Zhao Yangyu Y Yin Nanlin N Qi Hongbo H
Archives of medical science : AMS 20220223 2
<h4>Introduction</h4>There is an urgent need to find novel stable cell-free fetal (cff-) RNA in the maternal circulation to facilitate the advance of non-invasive prenatal testing (NIPT) to more effectively avoid birth defects.<h4>Methods</h4>CircRNA microarray was used to detect the cff-circRNA in plasma.<h4>Results</h4>There were cff-circRNAs from the fetus in the peripheral blood of pregnant women and they persisted even until at least 24 h after delivery. In addition, we found that cff-circR ...[more]
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