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Synthesis of phosphatidic acids via cobalt(salen) catalyzed epoxide ring-opening with dibenzyl phosphate.

ABSTRACT: With a CoIII(salen)OTs catalyst, dibenzyl phosphate ring-opens a variety of terminal epoxides with excellent regio-selectively and yields up to 85%. The reaction is used in a highly efficient synthesis of enantiopure mixed-diacyl phosphatidic acids, including a photoswitchable phosphatidic acid mimic.

SUBMITTER: Andringa RLH

PROVIDER: S-EPMC8924959 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Synthesis of phosphatidic acids <i>via</i> cobalt(salen) catalyzed epoxide ring-opening with dibenzyl phosphate.

Andringa Ruben L H RLH Jonker Marijn M Minnaard Adriaan J AJ

Organic & biomolecular chemistry 20220316 11

With a CoIII(salen)OTs catalyst, dibenzyl phosphate ring-opens a variety of terminal epoxides with excellent regio-selectively and yields up to 85%. The reaction is used in a highly efficient synthesis of enantiopure mixed-diacyl phosphatidic acids, including a photoswitchable phosphatidic acid mimic. ...[more]

PMID: 35253820

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