Ontology highlight
ABSTRACT:
SUBMITTER: Ou C
PROVIDER: S-EPMC8930617 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Ou Chong C Prabhu Sunaina Kiran SK Zhang Xiao X Zong Guanghui G Yang Qiang Q Wang Lai-Xi LX
Chemistry (Weinheim an der Bergstrasse, Germany) 20220221 16
Monoclonal antibodies (mAbs) are one of the most rapidly growing drug classes used for the treatment of cancer, infectious and autoimmune diseases. Complement-dependent cytotoxicity (CDC) is one of the effector functions for antibodies to deplete target cells. We report here an efficient chemoenzymatic synthesis of structurally well-defined conjugates of a monoclonal antibody with a rhamnose- and an αGal trisaccharide-cluster to recruit natural anti-rhamnose and anti-αGal antibodies, respectivel ...[more]