Trajectory of immune evasion and cancer progression in hepatocellular carcinoma.
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ABSTRACT:
SUBMITTER: Nguyen PHD
PROVIDER: S-EPMC8931110 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Publications
Trajectory of immune evasion and cancer progression in hepatocellular carcinoma.
Nguyen Phuong H D PHD Wasser Martin M Tan Chong Teik CT Lim Chun Jye CJ Lai Hannah L H HLH Seow Justine Jia Wen JJW DasGupta Ramanuj R Phua Cheryl Z J CZJ Ma Siming S Yang Jicheng J Suthen Sheena D/O SD Tam Wai Leong WL Lim Tony K H TKH Yeong Joe J Leow Wei Qiang WQ Pang Yin Huei YH Soon Gwyneth G Loh Tracy Jiezhen TJ Wan Wei Keat WK Chan Chung Yip CY Cheow Peng Chung PC Toh Han Chong HC Kow Alfred A Dan Yock Young YY Kam Juinn Huar JH Iyer Shridhar S Madhavan Krishnakumar K Chung Alexander A Bonney Glenn K GK Goh Brian K P BKP Fu Naiyang N Yu Victor C VC Zhai Weiwei W Albani Salvatore S Chow Pierce K H PKH Chew Valerie V
Nature communications 20220317 1
Immune evasion is key to cancer initiation and later at metastasis, but its dynamics at intermediate stages, where potential therapeutic interventions could be applied, is undefined. Here we show, using multi-dimensional analyses of resected tumours, their adjacent non-tumour tissues and peripheral blood, that extensive immune remodelling takes place in patients with stage I to III hepatocellular carcinoma (HCC). We demonstrate the depletion of anti-tumoural immune subsets and accumulation of im ...[more]
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