Goal discrimination in hippocampal nonplace cells when place information is ambiguous.
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ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC8931233 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Publications
Goal discrimination in hippocampal nonplace cells when place information is ambiguous.
Zhang Lu L Prince Stephanie M SM Paulson Abigail L AL Singer Annabelle C AC
Proceedings of the National Academy of Sciences of the United States of America 20220307 11
SignificanceGoal-directed spatial navigation has been found to rely on hippocampal neurons that are spatially modulated. We show that "nonplace" cells without significant spatial modulation play a role in discriminating goals when environmental cues for goals are ambiguous. This nonplace cell activity is performance-dependent and is modulated by gamma oscillations. Finally, nonplace cell goal discrimination coding fails in a mouse model of Alzheimer's disease (AD). Together, these results show t ...[more]
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