Ontology highlight
ABSTRACT:
SUBMITTER: Srinivasan L
PROVIDER: S-EPMC8935509 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Srinivasan Lakshmi L Alzogaray Vanina V Selvakumar Dakshnamurthy D Nathan Sara S Yoder Jesse B JB Wright Katharine M KM Klinke Sebastián S Nwafor Justin N JN Labanda María S MS Goldbaum Fernando A FA Schön Arne A Freire Ernesto E Tomaselli Gordon F GF Amzel L Mario LM Ben-Johny Manu M Gabelli Sandra B SB
The Journal of biological chemistry 20220221 4
Voltage-gated sodium channels, Na<sub>V</sub>s, are responsible for the rapid rise of action potentials in excitable tissues. Na<sub>V</sub> channel mutations have been implicated in several human genetic diseases, such as hypokalemic periodic paralysis, myotonia, and long-QT and Brugada syndromes. Here, we generated high-affinity anti-Na<sub>V</sub> nanobodies (Nbs), Nb17 and Nb82, that recognize the Na<sub>V</sub>1.4 (skeletal muscle) and Na<sub>V</sub>1.5 (cardiac muscle) channel isoforms. Th ...[more]