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ABSTRACT: Purpose
We investigated whether administration of the long-acting uterus stimulant carbetocin increased intra-subject sonication efficiency during Magnetic Resonance image guided High Intensity Focused Ultrasound (MR-HIFU) treatment of uterine fibroids.Method
In this prospective cohort study, thirty women with symptomatic uterine fibroids undergoing MR-HIFU treatment were included between January 2018 and January 2019. Treatment started with three sonications on one side of the uterine fibroid. Subsequently, one ampoule of 1 mL carbetocin (100 µg/mL) was administered intravenously and treatment continued with three sonications on the other side of the uterine fibroid. We compared the intra-subject sonication efficiency, in terms of Energy Efficiency Factor (EEF), thermal dose volume and sonication time to ablate one cm3 of fibroid tissue, before and after carbetocin administration. Adverse events that occurred within 30 min after carbetocin administration were recorded.Results
Sonication efficiency improved after carbetocin administration as indicated by a significant decrease in EEF and sonication time (p = 0.006 and p = 0.001 respectively), and a significant increase in thermal dose volume reached (p = <0.001). Five women (16.7%) experienced temporary tachycardia, one women in combination with headache, within 30 min after carbetocin administration.Conclusion
Administration of the long-acting uterus stimulant carbetocin improved the MR-HIFU treatment intra-subject sonication efficiency in women with symptomatic uterine fibroids.
SUBMITTER: Anneveldt KJ
PROVIDER: S-EPMC8942847 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Anneveldt Kimberley J KJ van 't Oever Heleen J HJ Verpalen Inez M IM Nijholt Ingrid M IM Bartels Wilbert W Dijkstra Jeroen R JR van den Hoed Rolf D RD van 't Veer-Ten Kate Miranda M de Boer Erwin E Veersema Sebastiaan S Huirne Judith A F JAF Schutte Joke M JM Boomsma Martijn F MF
European journal of radiology open 20220321
<h4>Purpose</h4>We investigated whether administration of the long-acting uterus stimulant carbetocin increased intra-subject sonication efficiency during Magnetic Resonance image guided High Intensity Focused Ultrasound (MR-HIFU) treatment of uterine fibroids.<h4>Method</h4>In this prospective cohort study, thirty women with symptomatic uterine fibroids undergoing MR-HIFU treatment were included between January 2018 and January 2019. Treatment started with three sonications on one side of the u ...[more]