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Covalent Attachment of Aggregation-Induced Emission Molecules to the Surface of Ultrasmall Gold Nanoparticles to Enhance Cell Penetration.

ABSTRACT: Three different alkyne-terminated aggregation-induced emission molecules based on a para-substituted di-thioether were attached to the surface of ultrasmall gold nanoparticles (2 nm) by copper-catalyzed azide-alkyne cycloaddition (click chemistry). They showed a strong fluorescence and were well water-dispersible, in contrast to the dissolved AIE molecules. The AIE-loaded nanoparticles were not cytotoxic and easily penetrated the membrane of HeLa cells, paving the way for an intracellular application of AIE molecules, e.g., for imaging.

SUBMITTER: Klein K

PROVIDER: S-EPMC8949416 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Covalent Attachment of Aggregation-Induced Emission Molecules to the Surface of Ultrasmall Gold Nanoparticles to Enhance Cell Penetration.

Klein Kai K Hayduk Matthias M Kollenda Sebastian S Schmiedtchen Marco M Voskuhl Jens J Epple Matthias M

Molecules (Basel, Switzerland) 20220309 6

Three different alkyne-terminated aggregation-induced emission molecules based on a <i>para</i>-substituted di-thioether were attached to the surface of ultrasmall gold nanoparticles (2 nm) by copper-catalyzed azide-alkyne cycloaddition (click chemistry). They showed a strong fluorescence and were well water-dispersible, in contrast to the dissolved AIE molecules. The AIE-loaded nanoparticles were not cytotoxic and easily penetrated the membrane of HeLa cells, paving the way for an intracellular ...[more]

PMID: 35335152

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