Ontology highlight
ABSTRACT:
SUBMITTER: Hormann AA
PROVIDER: S-EPMC8949806 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Hörmann Anton Amadeus AA Plhak Elisabeth E Klingler Maximilian M Rangger Christine C Pfister Joachim J Schwach Gert G Kvaternik Herbert H von Guggenberg Elisabeth E
Molecules (Basel, Switzerland) 20220321 6
The new minigastrin analog DOTA-MGS8 targeting the cholecystokinin-2 receptor (CCK2R) used in this study displays the combination of two site-specific modifications within the C-terminal receptor binding sequence together with an additional N-terminal amino acid substitution preventing fast metabolic degradation. Within this study, the preparation of <sup>68</sup>Ga-labeled DOTA-MGS8 was validated using an automated synthesis module, describing the specifications and analytical methods for quali ...[more]