PARP Inhibitors as Monotherapy in Daily Practice for Advanced Prostate Cancers.
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ABSTRACT:
SUBMITTER: Teyssonneau D
PROVIDER: S-EPMC8952857 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Publications
PARP Inhibitors as Monotherapy in Daily Practice for Advanced Prostate Cancers.
Teyssonneau Diego D Thiery-Vuillemin Antoine A Dariane Charles C Barret Eric E Beauval Jean-Baptiste JB Brureau Laurent L Créhange Gilles G Fiard Gaëlle G Fromont Gaëlle G Gauthé Mathieu M Ruffion Alain A Renard-Penna Raphaële R Mathieu Romain R Sargos Paul P Rouprêt Morgan M Ploussard Guillaume G Roubaud Guilhem G On Behalf Of The Cc-Afu Cancerology Committee Of The Association Française d'Urologie
Journal of clinical medicine 20220321 6
Despite recent improvements in survival, metastatic castration-resistant prostate cancers (mCRPCs) remain lethal. Alterations in genes involved in the homologous recombination repair (HRR) pathway are associated with poor prognosis. Poly-ADP-ribose polymerase (PARP) inhibitors (PARPis) have demonstrated anti-tumoral effects by synthetic lethality in patients with mCRPCs harboring HRR gene alterations, in particular <i>BRCA2</i>. While both olaparib and rucaparib have obtained government approval ...[more]
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