The Challenge and Opportunity of NTRK Inhibitors in Non-Small Cell Lung Cancer.
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ABSTRACT:
SUBMITTER: Qin H
PROVIDER: S-EPMC8954929 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Publications
The Challenge and Opportunity of NTRK Inhibitors in Non-Small Cell Lung Cancer.
Qin Haixia H Patel Manish R MR
International journal of molecular sciences 20220308 6
With the development of targeted therapy, non-small cell lung cancer (NSCLC) patients could have more treatment choices if target mutation presents. The neurotrophic tropomyosin receptor kinase (NTRK) has a low prevalence in NSCLC, roughly around 0.5%. FDA had approved two first generation NTRK inhibitors, larotrectinib and entrectinib. Both medications have excellent CNS penetration. This manuscript will review available data on targeting NTRK fusions in NSCLC and mechanisms of drug resistance. ...[more]
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