Bioavailability by design - Vitamin D₃ liposomal delivery vehicles.

ABSTRACT: Vitamin D3 deficiency has serious health consequences, as demonstrated by its effect on severity and recovery after COVID-19 infection. Because of high hydrophobicity, its absorption and subsequent redistribution throughout the body are inherently dependent on the accompanying lipids and/or proteins. The effective oral vitamin D₃ formulation should ensure penetration of the mucus layer followed by internalization by competent cells. Isothermal titration calorimetry and computer simulations show that vitamin D₃ molecules cannot leave the hydrophobic environment, indicating that their absorption is predominantly driven by the digestion of the delivery vehicle. In the clinical experiment, liposomal vitamin D₃ was compared to the oily formulation. The results o

SUBMITTER: Dalek P 

PROVIDER: S-EPMC8957331 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature