Dataset Information

A population-based study in synchronous versus metachronous metastatic esophagogastric adenocarcinoma.

ABSTRACT:

Background

Real-world data on treatment and outcomes in patients with synchronous metastatic disease compared with patients with metachronous metastatic disease in esophagogastric cancer have not been published before. The aim of our study was to explore treatment, overall survival (OS), and time to treatment fialure (TTF) in patients with synchronous and metachronous metastatic esophagogastric adenocarcinoma.

Methods

Patients with synchronous metastatic disease (2015-2017) and patients with metachronous metastatic disease initially treated with curative intent for nonmetastatic disease (2015-2016) were selected from the Netherlands Cancer Registry. OS and TTF were assessed from metastatic diagnosis for patients with synchronous, early metachronous (⩽6 months) or late metachronous (>6 months) metastatic disease using Kaplan-Meier curves with two-sided log-rank test.

Results

Median OS was 4.2, 2.1, and 4.4 months in patients with synchronous, early metachronous, and late metachronous metastatic disease, respectively (p < 0.001). The proportion of patients receiving systemic treatment was 41.3%, 21.5%, and 32.5% for synchronous, early metachronous, and late metachronous metastatic disease, respectively (p = 0.001). Among patients receiving systemic treatment, median OS was 8.8, 4.5, and 9.1 months (p < 0.001) and median TTF was 6.1, 3.8, and 5.7 months (p < 0.001) in synchronous, early metachronous, and late metachronous metastatic disease, respectively.

Conclusion

Patients with early metachronous metastatic disease have a worse survival compared with patients with synchronous or late metachronous metastatic disease. These patients less often receive systemic treatment, and even when treated, survival is worse compared with patients with synchronous or late metachronous metastatic disease, suggesting a more aggressive tumor behavior.

SUBMITTER: Pape M

PROVIDER: S-EPMC8958715 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

A population-based study in synchronous <i>versus</i> metachronous metastatic esophagogastric adenocarcinoma.

Pape Marieke M Vissers Pauline A J PAJ Bertwistle David D McDonald Laura L Slingerland Marije M Haj Mohammad Nadia N Beerepoot Laurens V LV Ruurda Jelle P JP Nieuwenhuijzen Grard A P GAP Jeene Paul M PM van Laarhoven Hanneke W M HWM Verhoeven Rob H A RHA

Therapeutic advances in medical oncology 20220324

<h4>Background</h4>Real-world data on treatment and outcomes in patients with synchronous metastatic disease compared with patients with metachronous metastatic disease in esophagogastric cancer have not been published before. The aim of our study was to explore treatment, overall survival (OS), and time to treatment fialure (TTF) in patients with synchronous and metachronous metastatic esophagogastric adenocarcinoma.<h4>Methods</h4>Patients with synchronous metastatic disease (2015-2017) and pa ...[more]

PMID: 35356260

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