Recent advancements in lipid-mRNA nanoparticles as a treatment option for cancer immunotherapy.

ABSTRACT:

Background

Cancer remains a serious health concern worldwide, and different approaches are being developed for its treatment. The strategy to use the immune system as an approach for treating cancer has recently gained momentum. Messenger RNA (mRNA) has been assessed as an up-and-coming resource for the evolution of advanced cancer immunotherapies over the past decades. However, degradation in extracellular compartments and during endosomal escape remain obstacles for efficient mRNA delivery and limit the therapeutic applications of this approach.

Area covered

Lipid-based nanocarriers are gaining significant attention as non-viral mRNA vectors. Various lipid-based nanocarrier types have been developed to enhance the stability of mRNA molecules, facilitate their transfection,

SUBMITTER: Karmacharya P 

PROVIDER: S-EPMC8960215 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature