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Characterization of a Mycobacterium smegmatis mutant lacking penicillin binding protein 1.

ABSTRACT: The ponA gene of Mycobacterium smegmatis encodes a 95-kDa penicillin binding protein, PBP1, that is similar to PBP1s of Mycobacterium tuberculosis and Mycobacterium leprae. Transposon disruption of ponA in M. smegmatis resulted in a PBP1-deficient mutant that was sensitive to beta-lactam antibiotics, was more permeable to glycine, and grew slowly in liquid culture.

SUBMITTER: Billman-Jacobe H 

PROVIDER: S-EPMC89605 | biostudies-literature | 1999 Dec

REPOSITORIES: biostudies-literature

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Characterization of a Mycobacterium smegmatis mutant lacking penicillin binding protein 1.

Billman-Jacobe H H   Haites R E RE   Coppel R L RL  

Antimicrobial agents and chemotherapy 19991201 12

The ponA gene of Mycobacterium smegmatis encodes a 95-kDa penicillin binding protein, PBP1, that is similar to PBP1s of Mycobacterium tuberculosis and Mycobacterium leprae. Transposon disruption of ponA in M. smegmatis resulted in a PBP1-deficient mutant that was sensitive to beta-lactam antibiotics, was more permeable to glycine, and grew slowly in liquid culture. ...[more]

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