Accelerated decline in white matter microstructure in subsequently impaired older adults and its relationship with cognitive decline.
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ABSTRACT:
SUBMITTER: Shafer AT
PROVIDER: S-EPMC8963308 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Accelerated decline in white matter microstructure in subsequently impaired older adults and its relationship with cognitive decline.
Shafer Andrea T AT Williams Owen A OA Perez Evian E An Yang Y Landman Bennett A BA Ferrucci Luigi L Resnick Susan M SM
Brain communications 20220301 2
Little is known about a longitudinal decline in white matter microstructure and its associations with cognition in preclinical dementia. Longitudinal diffusion tensor imaging and neuropsychological testing were performed in 50 older adults who subsequently developed mild cognitive impairment or dementia (subsequently impaired) and 200 cognitively normal controls. Rates of white matter microstructural decline were compared between groups using voxel-wise linear mixed-effects models. Associations ...[more]
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