Ontology highlight
ABSTRACT:
SUBMITTER: Sales-Lee J
PROVIDER: S-EPMC8967684 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Sales-Lee Jade J Perry Daniela S DS Bowser Bradley A BA Diedrich Jolene K JK Rao Beiduo B Beusch Irene I Yates John R JR Roy Scott W SW Madhani Hiten D HD
Current biology : CB 20210922 22
We determined that over 40 spliceosomal proteins are conserved between many fungal species and humans but were lost during the evolution of S. cerevisiae, an intron-poor yeast with unusually rigid splicing signals. We analyzed null mutations in a subset of these factors, most of which had not been investigated previously, in the intron-rich yeast Cryptococcus neoformans. We found they govern splicing efficiency of introns with divergent spacing between intron elements. Importantly, most of these ...[more]