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Mechanisms of resistance to quinupristin-dalfopristin among isolates of Enterococcus faecium from animals, raw meat, and hospital patients in Western Europe.


ABSTRACT: Twenty-eight quinupristin-dalfopristin-resistant isolates of Enterococcus faecium from hospital patients and nonhuman sources in European countries were studied. High-level resistance (MICs, >/=32 microg/ml) was associated with the presence of vat(E) (satG) (14 isolates ¿50%) or vat(D) (satA) (6 isolates ¿21%). These genes were not detected in eight (29%) isolates with lower levels of quinupristin-dalfopristin resistance (MICs, 4 to 16 microg/ml). This suggests the presence of further mechanisms of resistance to quinupristin-dalfopristin in E. faecium.

SUBMITTER: Soltani M 

PROVIDER: S-EPMC89699 | biostudies-literature | 2000 Feb

REPOSITORIES: biostudies-literature

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Mechanisms of resistance to quinupristin-dalfopristin among isolates of Enterococcus faecium from animals, raw meat, and hospital patients in Western Europe.

Soltani M M   Beighton D D   Philpott-Howard J J   Woodford N N  

Antimicrobial agents and chemotherapy 20000201 2


Twenty-eight quinupristin-dalfopristin-resistant isolates of Enterococcus faecium from hospital patients and nonhuman sources in European countries were studied. High-level resistance (MICs, >/=32 microg/ml) was associated with the presence of vat(E) (satG) (14 isolates ¿50%) or vat(D) (satA) (6 isolates ¿21%). These genes were not detected in eight (29%) isolates with lower levels of quinupristin-dalfopristin resistance (MICs, 4 to 16 microg/ml). This suggests the presence of further mechanisms  ...[more]

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