Dataset Information

Association between household size and COVID-19: A UK Biobank observational study.

ABSTRACT:

Objective

To assess the association between household size and risk of non-severe or severe COVID-19.

Design

A longitudinal observational study.

Setting

This study utilised UK Biobank linked to national SARS-CoV-2 laboratory test data.

Participants

401,910 individuals with available data on household size in UK Biobank.

Main outcome measures

Household size was categorised as single occupancy, two-person households and households of three or more. Severe COVID-19 was defined as a positive SARS-CoV-2 test on hospital admission or death with COVID-19 recorded as the underlying cause; and non-severe COVID-19 as a positive test from a community setting. Logistic regression models were fitted to assess associations, adjusting for potential confounders.

Results

Of 401,910 individuals, 3612 (1%) were identified as having suffered from a severe COVID-19 infection and 11,264 (2.8%) from a non-severe infection, between 16 March 2020 and 16 March 2021. Overall, the odds of severe COVID-19 was significantly higher among individuals living alone (adjusted odds ratio: 1.24 [95% confidence interval: 1.14 to 1.36], or living in a household of three or more individuals (adjusted odds ratio: 1.28 [1.17 to 1.39], when compared to individuals living in a household of two. For non-severe COVID-19 infection, individuals living in a single-occupancy household had lower odds compared to those living in a household of two (adjusted odds ratio: 0.88 [0.82 to 0.93].

Conclusions

Odds of severe or non-severe COVID-19 infection were associated with household size. Increasing understanding of why certain households are more at risk is important for limiting spread of the infection.

SUBMITTER: Gillies CL

PROVIDER: S-EPMC8972956 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Association between household size and COVID-19: A UK Biobank observational study.

Gillies Clare L CL Rowlands Alex V AV Razieh Cameron C Nafilyan Vahé V Chudasama Yogini Y Islam Nazrul N Zaccardi Francesco F Ayoubkhani Daniel D Lawson Claire C Davies Melanie J MJ Yates Tom T Khunti Kamlesh K

Journal of the Royal Society of Medicine 20220204 4

<h4>Objective</h4>To assess the association between household size and risk of non-severe or severe COVID-19.<h4>Design</h4>A longitudinal observational study.<h4>Setting</h4>This study utilised UK Biobank linked to national SARS-CoV-2 laboratory test data.<h4>Participants</h4>401,910 individuals with available data on household size in UK Biobank.<h4>Main outcome measures</h4>Household size was categorised as single occupancy, two-person households and households of three or more. Severe COVID- ...[more]

PMID: 35118908

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Dataset Information

Association between household size and COVID-19: A UK Biobank observational study.

Objective

Design

Setting

Participants

Main outcome measures

Results

Conclusions

Publications

Association between household size and COVID-19: A UK Biobank observational study.

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