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[Research Progress of Antibody-drug Conjugates in Advanced Non-small Cell Lung Cancer].

ABSTRACT: Lung cancer is one of the malignant tumors with the highest morbidity and mortality in the world. Non-small cell lung cancer (NSCLC) is one of the most important pathological types of lung cancer. The prognosis of advanced NSCLC is poor and medical treatment is still the main treatment option. Antibody-drug conjugates (ADCs) are the kind of potentially new anti-tumor drugs, consisting of monoclonal antibodies conjugated to the cytotoxic payloads via the synthetic linkers. They have a broad application prospect in solid tumors such as lung cancer. This article focuses on the mechanism of action and research progress of ADCs in advanced NSCLC. .

SUBMITTER: Wang N

PROVIDER: S-EPMC8976206 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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[Research Progress of Antibody-drug Conjugates in Advanced Non-small Cell Lung Cancer].

Wang Na N Zhao Lu L Zhang Dou D Jia Yingjie Y Kong Fanming F

Zhongguo fei ai za zhi = Chinese journal of lung cancer 20220301 3

Lung cancer is one of the malignant tumors with the highest morbidity and mortality in the world. Non-small cell lung cancer (NSCLC) is one of the most important pathological types of lung cancer. The prognosis of advanced NSCLC is poor and medical treatment is still the main treatment option. Antibody-drug conjugates (ADCs) are the kind of potentially new anti-tumor drugs, consisting of monoclonal antibodies conjugated to the cytotoxic payloads via the synthetic linkers. They have a broad appli ...[more]

PMID: 35340165

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