Variation in PARK10 is not associated with risk and age at onset of Parkinson's disease in large clinical cohorts.
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ABSTRACT:
SUBMITTER: Simon-Sanchez J
PROVIDER: S-EPMC8978882 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
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Variation in PARK10 is not associated with risk and age at onset of Parkinson's disease in large clinical cohorts.
Simón-Sánchez Javier J Heutink Peter P Gasser Thomas T
Neurobiology of aging 20150710 10
A recent study in autopsy-confirmed Parkinson's disease (PD) patients and controls revived the debate about the role of PARK10 in this disorder. In an attempt to replicate these results and further understand the role of this locus in the risk and age at onset of PD, we decided to explore NeuroX genotyping and whole exome sequencing data from 2 large independent cohorts of clinical patients and controls from the International Parkinson's Disease Genomic Consortium. A series of single-variant and ...[more]
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