Repurposing drugs as COVID-19 therapies: A toxicity evaluation.
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ABSTRACT:
SUBMITTER: Ngan DK
PROVIDER: S-EPMC8983078 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Publications
Repurposing drugs as COVID-19 therapies: A toxicity evaluation.
Ngan Deborah K DK Xu Tuan T Xia Menghang M Zheng Wei W Huang Ruili R
Drug discovery today 20220406 7
Drug repurposing is an appealing method to address the Coronavirus 2019 (COVID-19) pandemic because of the low cost and efficiency. We analyzed our in-house database of approved drug screens and compared their activity profiles with results from a severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) cytopathic effect (CPE) assay. The activity profiles of the human ether-à-go-go-related gene (hERG), phospholipidosis (PLD), and many cytotoxicity screens were found significantly correlated ...[more]
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