Dataset Information

Assessing the cost-effectiveness of precision medicine: protocol for a systematic review and meta-analysis.

ABSTRACT:

Introduction

Precision medicine (PM) involves gene testing to identify disease risk, enable early diagnosis or guide therapeutic choice, and targeted gene therapy. We aim to perform a systematic review and meta-analysis to quantify the cost-effectiveness profile of PM stratified by intervention type, identify sources of heterogeneity in the value-for-money of PM.

Methods and analysis

We will perform a systematic search in Embase, MEDLINE, EconLit and CRD databases for studies published in English language or with translation in English between 1 January 2011 and 8 July 2021 on the topic of cost-effectiveness analysis of PM interventions. The focus will be on studies that reported health and economic outcomes. Study quality will be assessed using the Biases in Economic Studies checklist. The incremental net benefit of PM screening, diagnostic, treatment-targeting and therapeutic interventions over conventional strategies will be respectively pooled across studies using a random-effect model if heterogeneity is present, otherwise a fixed-effect model. Subgroup analyses will be performed based on disease area, WHO region and World Bank country-income level. Additionally, we will identify the potential sources of heterogeneity with random-effect meta-regressions. Finally, biases will be detected using jackknife sensitivity analysis, funnel plot assessment and Egger's tests.

Ethics and dissemination

For this type of study ethics approval or formal consent is not required. The results will be disseminated at various presentations and feedback sessions, in conference abstracts and manuscripts that will be submitted to peer-reviewed journals.

Prospero registration number

CRD42021272956.

SUBMITTER: Chen W

PROVIDER: S-EPMC8984003 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Assessing the cost-effectiveness of precision medicine: protocol for a systematic review and meta-analysis.

Chen Wenjia W Anothaisintawee Thunyarat T Butani Dimple D Wang Yi Y Zemlyanska Yaroslava Y Wong Chong Boon Nigel CBN Virabhak Suchin S Hrishikesh M A MA Teerawattananon Yot Y

BMJ open 20220405 4

<h4>Introduction</h4>Precision medicine (PM) involves gene testing to identify disease risk, enable early diagnosis or guide therapeutic choice, and targeted gene therapy. We aim to perform a systematic review and meta-analysis to quantify the cost-effectiveness profile of PM stratified by intervention type, identify sources of heterogeneity in the value-for-money of PM.<h4>Methods and analysis</h4>We will perform a systematic search in Embase, MEDLINE, EconLit and CRD databases for studies publ ...[more]

PMID: 35383079

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Dataset Information

Assessing the cost-effectiveness of precision medicine: protocol for a systematic review and meta-analysis.

Introduction

Methods and analysis

Ethics and dissemination

Prospero registration number

Publications

Assessing the cost-effectiveness of precision medicine: protocol for a systematic review and meta-analysis.

Similar Datasets

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