Characterization of a class II ketol-acid reductoisomerase from Mycobacterium tuberculosis.
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ABSTRACT:
SUBMITTER: Valera A
PROVIDER: S-EPMC8985424 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
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Characterization of a class II ketol-acid reductoisomerase from <i>Mycobacterium tuberculosis</i>.
Valera Ane A Wang Shan S Carr Reuben R Trembleau Laurent L Deng Hai H
RSC advances 20220301 17
<i>Mycobacterium tuberculosis</i> ketol-acid reductoisomerases have been widely studied due to their metabolic importance towards development of drug-resistant bacteria treatment. We here report the biochemical characterization of a new KARI (MtKARI-II) from a <i>Mycobacterium tuberculosis</i> variant with a similar kinetic profile to class I KARIs. Phylogenetic analysis suggested that MtKARI-II is clustered into a class II KARI superfamily. ...[more]
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