Dataset Information

On the interrelation between alcohol addiction-like behaviors in rats.

ABSTRACT:

Rationale

Alcohol use disorder (AUD) is a complex, heterogeneous disorder that only occurs in a minority of alcohol users. Various behavioral constructs, including excessive intake, habit formation, motivation for alcohol and resistance to punishment have been implicated in AUD, but their interrelatedness is unclear.

Objective

The aim of this study was therefore to explore the relation between these AUD-associated behavioral constructs in rats. We hypothesised that a subpopulation of animals could be identified that, based on these measures, display consistent AUD-like behavior.

Methods

Lister Hooded rats (n = 47) were characterised for alcohol consumption, habit formation, motivation for alcohol and quinine-adulterated alcohol consumption. The interrelation between these measures was evaluated through correlation and cluster analyses. In addition, addiction severity scores were computed using different combinations of the behavioral measures, to assess the consistency of the AUD-like subpopulation.

Results

We found that the data was uniformly distributed, as there was no significant tendency of the behavioral measures to cluster in the dataset. On the basis of multiple ranked addiction severity scores, five animals (~ 11%) were classified as displaying AUD-like behavior. The composition of the remaining subpopulation of animals with the highest addiction severity score (9 rats; ~ 19%) varied, depending on the combination of measures included.

Conclusion

Consistent AUD-like behavior was detected in a small proportion of alcohol drinking rats. Alcohol consumption, habit formation, motivation for alcohol and punishment resistance contribute in varying degrees to the AUD-like phenotype across the population. These findings emphasise the importance of considering the heterogeneity of AUD-like behavior.

SUBMITTER: Smeets JAS

PROVIDER: S-EPMC8986720 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Publications

On the interrelation between alcohol addiction-like behaviors in rats.

Smeets Johanna A S JAS Minnaard A Maryse AM Ramakers Geert M J GMJ Adan Roger A H RAH Vanderschuren Louk J M J LJMJ Lesscher Heidi M B HMB

Psychopharmacology 20220112 4

<h4>Rationale</h4>Alcohol use disorder (AUD) is a complex, heterogeneous disorder that only occurs in a minority of alcohol users. Various behavioral constructs, including excessive intake, habit formation, motivation for alcohol and resistance to punishment have been implicated in AUD, but their interrelatedness is unclear.<h4>Objective</h4>The aim of this study was therefore to explore the relation between these AUD-associated behavioral constructs in rats. We hypothesised that a subpopulation ...[more]

PMID: 35020046

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Dataset Information

On the interrelation between alcohol addiction-like behaviors in rats.

Rationale

Objective

Methods

Results

Conclusion

Publications

On the interrelation between alcohol addiction-like behaviors in rats.

Similar Datasets

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